Chemical stability of fentanyl in polypropylene syringes and polyvinylchloride bags.
Bibliographic record
Abstract
Fentanyl is a potent synthetic lipophilic opiate agonist used to control pain as a single agent or in combination with local anesthetics. The chemical stability of the undiluted commercial solution (50 micrograms/mL) in polypropylene syringes or polyvinylchloride bags has never been reported. Undiluted fentanyl solution, 50 micrograms/mL, was aseptically transferred to polypropylene syringes or polyvinylchloride bags. Samples were then stored, either at 5 deg C and protected from light, or at 22 deg C and exposed to light, for 28 days. A stability-indicating high-performance liquid chromatographic method was used to monitor the fentanyl concentration of the samples. Color, clarity, and pH also were monitored. After storage for 28 days, there were no signs of chemical degradation of fentanyl packaged in either polypropylene syringes or polyvinylchloride bags at either 5 deg C or 22 deg C. All solutions remained colorless and clear over the course of the study. The pH did not change significantly after storage for 28 days. Fentanyl solutions, when packaged undiluted in polypropylene syringes or polyvinylchloride bags, are chemically stable for 28 days when stored either at 5 deg C and protected from light or at 22 deg C and exposed to light.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".