Abstract W P136: Aiding Stroke Rehabilitation with the Modified Atkins Diet: A Pilot Trial
Bibliographic record
Abstract
Introduction: The Modified Atkins Diet (MAD) is a low carbohydrate, ketogenic diet. Animal studies suggest ketogenic diets enhance functional stroke recovery by activating transcriptional programs associated with brain protection and repair. The safety of use of the MAD in the elderly stroke population is however unknown. We here expand the use of MAD in a new patient population. Setting: Inpatient Stroke Rehabilitation Unit Methods: 18 first time ischemic stroke patients were randomized to receive either the MAD or their respective regular diet. Laboratory studies were obtained upon admission and every 5 days until discharge. Functional outcome measures included the Upper Extremity Fugl Meyer Motor Score (FMMS), Functional Independence Measure (FIM) and Montreal Cognitive Assessment (MOCA). Urine was tested daily for presence of ketones. A registered dietician monitored patients daily. All patients received cholesterol-lowering medication. Results: 10 patients received the MAD and 8 respective control diets. Age, gender, and interval post stroke did not differ significantly between groups. No significant difference existed between groups in admission cognitive, motor and total FIM scores, FMMS and MOCA scores. 4 patients withdrew prematurely from the MAD group due to low palatability of a pureed diet with nectar thick liquids. No significant medical events were encountered in either group. The MAD did not induce significant changes in LDL (-13.8±29.7 vs. -7.5±19.2;p=0.59), cholesterol (-9.2±36.5 vs. -10.8±25.22;p=0.92) and glucose levels (14±28.5 vs. -0.38±20.5;p=0.4).The MAD and Control group had similar changes in total (30.9,±12.3 vs. 25.9±11.9;p=0.5), motor (18.8±14.5 vs. 18.5±13.1;p=0.62), cognitive FIM (4.5,±2.3 vs. 5±3.5;p=0.4),FMMS(15.2±5.01 vs. 17.8±11.6;p=0.65),and MOCA scores (6.2±5.2 vs. 4.6±2.96;p=0.57). Conclusion: The Modified Atkins Diet is a safe and feasible intervention to aide stroke recovery. No adverse effects on lipid and glucose profile were noted, and the diet was overall well tolerated. A larger, multi-center trial will be needed to test for efficacy. The study also highlights the advantages of the rehab setting for implementing dietary interventions post stroke and verifying compliance.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".