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Record W1545460826 · doi:10.1196/annals.1317.006

The Glucagon‐Like Peptides

2006· article· en· W1545460826 on OpenAlexaff
Patricia L. Brubaker

Bibliographic record

VenueAnnals of the New York Academy of Sciences · 2006
Typearticle
Languageen
FieldMedicine
TopicDiabetes Treatment and Management
Canadian institutionsCanada Research ChairsUniversity of Toronto
Fundersnot available
KeywordsAssimilation (phonology)IngestionGastrointestinal tractGlucagon-like peptide-1HomeostasisDigestion (alchemy)Glucagon-like peptide-2PancreasNutrient sensingNutrientGlucagonGlucose homeostasisIntestinal epitheliumChemistryBiologyEndocrinologyInternal medicineEpitheliumBiochemistryPeptideMedicineInsulinSignal transductionDiabetes mellitus

Abstract

fetched live from OpenAlex

The glucagon-like peptides, GLP-1 and GLP-2, are cosecreted by intestinal L cells in response to nutrient ingestion. These peptides exert multiple effects on the gastrointestinal tract and pancreas to regulate the digestion, absorption, and assimilation of ingested nutrients, as well as providing feedback signals to the brain to modulate food intake. Tropic effects of GLP-1 and GLP-2 on their major peripheral target tissues, the beta cell and the intestinal epithelium, respectively, further enhance capacity for nutrient handling. When taken together, these findings demonstrate the diverse actions of the intestinal glucagon-like peptides to regulate nutrient homeostasis.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.352
Threshold uncertainty score0.284

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.065
GPT teacher head0.327
Teacher spread0.262 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations109
Published2006
Admission routes1
Has abstractyes

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