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Record W1547741074

MULE DEER (ODOCOILEUS HEMIONUS) REPRODUCTION, FAWN SURVIVAL, AND EXPOSURE OF FAWNS TO INFECTIOUS AGENTS IN A CHRONIC WASTING DISEASE ENDEMIC AREA OF SOUTHERN SASKATCHEWAN

2012· article· en· W1547741074 on OpenAlexaboutno aff
A. M. Perera

Bibliographic record

VenueUniversity Library - University of Saskatchewan (University of Saskatchewan) · 2012
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPrion Diseases and Protein Misfolding
Canadian institutionsnot available
Fundersnot available
KeywordsChronic wasting diseaseOdocoileusWastingReproductionBiologyColonizationDiseaseInfectious disease (medical specialty)MedicineZoologyEcologyInternal medicine
DOInot available

Abstract

fetched live from OpenAlex

As a part of an ongoing study of the geographic spread and long term population effects of chronic wasting disease (CWD) in southwestern Saskatchewan, we captured and radio-collared female mule deer (Odocoileus hemionus) in the winter of 2009, 2010 and 2011 and, in the subsequent spring, we captured their newborn fawns. Fawns were blood sampled, radio-collared and ear tagged, released and then continuously monitored for survival status until the following February or March. During the winter capture we also sampled blood, tonsils and feces from juvenile mule deer which were approximately 8 months old. Our primary objectives were to 1) estimate female reproductive indices and evaluate fawn survival rates within the first 8 months of life and 2) detect exposure to selected infectious agents in neonates and 8-month old juveniles. Pregnancy rate, as determined by ultrasound in 2010 and 2011 winter was 100% (n=84); the overall average number of fetuses per doe was 1.99 ± SD 0.33 (167 fetuses, 84 does) with a predominance of twins. Mean birth rate was 1.29 ± SD 0.72 fawns per doe (139 neonates, 108 does). During the 3 capture years, we captured and radio-collared 118 neonates (n=38 in 2009, n=41 in 2010, n=39 in 2011). Probability of fawn survival was 0.334 ± SD 0.047 for the first 8 months of life from 2009 to 2011 and did not differ among capture years (P = 0.411). The most common known cause of mortality was predation. Having a longer body length at birth reduced the risk of fawn death for 0 - 7 day postpartum period. Members of larger litters had a higher risk of death during 8 – 30 day postpartum period. However, subclinical CWD status of dam was a poor predictor of fawn survival during the first 8 months of life. We performed various laboratory tests on feces, blood and tonsils of 8-month-old deer to detect prevalence of parasitic agents shed in feces, CWD in tonsils, mule deer lymphotropic herpes virus (mule deer-LHV) in buffy coat and presence of antibody titers in serum to bovine viral diarrhoea virus (BVDV), bovine herpes virus-1 (BHV-1), parainfluenza 3 virus (PI3), and the protozoan parasite Neospora caninum. Fecal analysis revealed a high prevalence for Orthostrongylus sp.: 86% (80/93), and moderate prevalence for Moniezia: 29% (27/93) and Thysanasoma: 29% (27/93). Seroprevalence for BHV-1, BVDV, PI3 virus and Neospora caninum was 3% (3/92), 20% (19/93), 22% (20/93), and 3% (3/91) respectively. Prevalence of mule deer-LHV was 15% (13/85). In 2010 and 2011, we detected subclinical CWD infection in 2 and 1 juveniles, respectively, with an overall prevalence of 3% (3/95). Serology on neonate blood revealed 12% (13/106) were seropositive for N. caninum and all dams that were seropositive for Neospora gave birth to at least one fawn. Mule deer in the Antelope Creek area of southwestern Saskatchewan have low fawn survival rates which may, in combination with high adult mortality due to hunting or CWD, result in population declines. Given the long incubation of CWD, even a low prevalence of CWD in 8 month old fawns suggests high infection pressure on resident deer. The high prevalence of gastrointestinal parasites and moderate seroprevalence for BVDV and PI3 virus at 8 months of age indicates frequent exposure to pathogens spread via the environment and by direct transmission. Because these are routes of transmission shared by CWD, this moderate to high prevalence of exposure to infectious agents also supports the hypothesis that fawns are potentially exposed to CWD at a young age. To understand factors responsible for the observed annual variability in exposure to Orthostrongylus, BVDV, and PI3 virus requires investigation of these infectious agents in sympatric species including livestock in the area.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.649
Threshold uncertainty score0.697

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.190
Teacher spread0.179 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations1
Published2012
Admission routes1
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