Hydrogen sulphide acts in the subfornical organ and paraventricular nucleus to increase blood pressure (681.6)
Bibliographic record
Abstract
Hydrogen sulfide (H 2 S) is as an endogenous gaseous transmitter that has been shown to act in the central nervous system to influence variety of functions including cardiovascular function. Administration of H 2 S in the lateral ventricle has been shown to increase blood pressure although the specific nuclei responsible for mediating these effects have not been identified. The subfornical organ (SFO) in the forebrain and the hypothalamic paraventricular nucleus (PVN) are central nervous system structures with well‐documented roles in cardiovascular regulation. The present study was undertaken to determine the effects of direct administration of the hydrogen sulfide donor, sodium hydrogen sulfide (NaH 2 S),into the SFO and PVN in urethane anesthetized male Sprague Dawley rats. Microinjection of NaH 2 S (10mM, 0.5µl) into either the SFO or PVN resulted in increases in BP (SFO mean AUC = 663.3 ± 51.6 mmHg*s, n=5; PVN mean AUC 447.4 ± 66 mmHg*s, n=4) and HR (SFO mean AUC = 29.6 ± 5.9 beats, n=5; PVN mean AUC 10.7 ± 2.1 beats, n=4). These cardiovascular responses were of rapid onset (responses began within 10s of microinjection) and short duration, returning to baseline within 90s. In both cases, these responses were shown to be dose related and site specific. These observations identify the SFO and PVN as possible central nervous system locations at which H 2 S may act to influence cardiovascular regulation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".