Structure and chemistry of the human p300/CBP and yeast Rtt109 histone acetyltransferase
Bibliographic record
Abstract
Histone actyltransferase (HAT) enzymes form a superfamily of proteins that transfer an acetyl group from the acetyl‐coenzyme A (Ac‐CoA) cofactor to the epsilon amino group of histone or sometimes non‐histone proteins to promote gene activation. Paradoxally, despite the similar chemistry carried out by these enzymes, and their structurally related core regions, they fall into subfamilies with very limited to no sequence homology, structurally divergent core flanking regions and they use divergent mechanisms for catalysis. Four well studied HAT families include Gcn5/PCAF, MYST, p300/CBP and Rtt109. Although the structure and chemistry of the evolutionarily conserved Gcn5/PCAF and MYST HATs have been previously characterized, the metazoan‐specific p300/CBP and fungal‐specific Rtt109 have only recently been characterized at the structural and chemical levels. These recent studies provide new insights into the ancestral relationship between HATs and their functions and point to a common HAT ancestor that has evolved around a common structural framework to form HATs with divergent catalytic and substrate binding properties. These studies also point to the importance of regulatory loops within HATs and autoacetylation in HAT function. Implications for future studies will also be discussed.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".