Amphotericin B-loaded bone cement to treat osteomyelitis caused by Candida albicans.
Bibliographic record
Abstract
in an adult who hadundergone multiple revisions of a hipprosthesis. Treatment was with ampho-tericin B-loaded bone cement. We be-lieve this is the first report of such treat-ment for fungal osteomyelitis.Case report A 59-year-old man (height 180 cm,weight 82 kg) was admitted to the Vancouver Hospital & Health SciencesCentre with a suspected infection after asecond revision total hip arthroplasty.His medical history included an undiag-nosed inflammatory arthropathy forwhich he had undergone a right-sidedtotal hip replacement in 7 years earlier.This had been revised twice because ofaseptic loosening, first 6 years after theoriginal replacement and subsequently 2months before the current admission.The erythrocyte sedimentation rate, C-reactive protein levels and intraoperativesynovial tissue cultures obtained at thetime of these revisions revealed no infec-tion. His course after the second revisionoperation was uncomplicated until 10days before this admission when he hadnight sweats, fever, redness and swellingover the right hip. He did not report anydrug allergies and only reported takingdiclofenac 50 mg orally twice daily, forhis inflammatory arthropathy. On admission, his vital signs includeda blood pressure of 165/90 mm Hg,heart rate of 110 beats/min, and a bodytemperature of 38.1°C. Findings onphysical examination were unremarkableexcept for an area of erythema over themedial portion of the wound on theright hip; the area from the right hipdown to the knee was also edematousand tender. Ultrasonography revealed asmall fluid collection from which 30 mLof turbid serosanguineous fluid was aspirated. This contained 19.7 × 10
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".