In Vitro Leukocyte Adhesion in Endothelial Tissue Culture Models Under Flow
Bibliographic record
Abstract
Atherosclerosis, an inflammatory disease which causes thickening and stiffening of arteries, is a major cause of death in the United States (Lloyd-Jones et al., 2010). These deaths occur because of vessel occlusion created by atherosclerotic plaques and thrombus shedding, leading to heart attack, ischemia, or stroke. Atherosclerosis is expected to be the leading cause of death worldwide within 10 years (Lloyd-Jones et al., 2010). Inflammation plays a significant role in the initiation and progression of atherosclerosis. The cells that line the arteries, endothelial cells (ECs), mediate the inflammatory process. The forces created by blood flow affect the inflammatory response of ECs and the interaction with blood components. This chapter summarizes the background in our recent studies on the response of ECs to blood forces and the interaction of inflammatory cells.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".