Gestational chronic intermittent hypoxia alters glucose homeostasis in rat male offspring (1072.3)
Bibliographic record
Abstract
We have shown that exposure to chronic intermittent hypoxia (CIH) during pregnancy results in offspring with increased fat deposition that are hyperglycemic, hyperinsulinemic, and have impaired early‐stage glucose tolerance in adulthood, but the underlying mechanisms are unknown. This study was done to examine changes in the glucoregulatory function of the liver as a result of CIH exposure during gestational development. Female Sprague‐Dawley rats were mated and exposed daily to CIH throughout gestation. Offspring were sacrificed at postnatal day‐1 or 6‐wks of age to determine immediate and long‐term changes in liver function. By 6 wks of age, male CIH offspring had higher plasma corticosterone concomitant with higher liver protein expression of 11β‐hydroxysteroid dehydrogenase type I and glucocorticoid receptor (GR). These were associated with lower liver X receptor (LXR) protein expression. Analysis of GR and LXR‐direct target genes in gluconeogenesis showed that glucose‐6‐phosphatase expression was higher in CIH offspring, while no changes in phosphoenolpyruvate carboxykinase protein levels were observed. Taken together, these data suggest that gestational exposure to CIH results in long‐term alteration of hepatic glucose homeostasis via increased glucocorticoid signaling and decreased regulation of gluconeogenic enzymes by LXR. Supported by HSF of Ontario and CIHR. Grant Funding Source : Heart and Stroke Foundation of Ontario and Canadian Institutes of Health Research
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".