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Record W1560837288 · doi:10.5772/31110

Nuclear Poly (A)-Binding Protein and Oculopharyngeal Muscular Dystrophy

2012· book-chapter· en· W1560837288 on OpenAlexaff
Jnanankur Bag, Quishan Wang, Rumpa Biswas

Bibliographic record

VenueInTech eBooks · 2012
Typebook-chapter
Languageen
FieldNeuroscience
TopicGenetic Neurodegenerative Diseases
Canadian institutionsUniversity of Guelph
Fundersnot available
KeywordsOculopharyngeal muscular dystrophyMuscular dystrophyPoly(A)-binding proteinMedicineGeneticsBiologyInternal medicineRNA-binding proteinGene

Abstract

fetched live from OpenAlex

Huntington is not clear. A slippage model, where the newly synthesized DNA strand dissociates and translocates to a new pairing position during DNA replication has been proposed. Perhaps this misalignment of the nascent strand in the repetitive tract results in the addition or deletion of repeats. Because of the stable nature of the GCG trinucleotide repeats of PABPN1 gene this model may not be applicable for the generation of mutation in OPMD patients. Unequal cross over during DNA replication may be the underlying mechanism for (GCG) repeat.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.256
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.240
Teacher spread0.212 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2012
Admission routes1
Has abstractyes

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