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Record W1560837288 · doi:10.5772/31110

Nuclear Poly (A)-Binding Protein and Oculopharyngeal Muscular Dystrophy

2012· book-chapter· en· W1560837288 on OpenAlexaff
Jnanankur Bag, Quishan Wang, Rumpa Biswas

Bibliographic record

VenueInTech eBooks · 2012
Typebook-chapter
Languageen
FieldNeuroscience
TopicGenetic Neurodegenerative Diseases
Canadian institutionsUniversity of Guelph
Fundersnot available
KeywordsOculopharyngeal muscular dystrophyMuscular dystrophyPoly(A)-binding proteinMedicineGeneticsBiologyInternal medicineRNA-binding proteinGene

Abstract

fetched live from OpenAlex

Muscular Dystrophy 26Huntington is not clear.A slippage model, where the newly synthesized DNA strand dissociates and translocates to a new pairing position during DNA replication has been proposed.Perhaps this misalignment of the nascent strand in the repetitive tract results in the addition or deletion of repeats.Because of the stable nature of the GCG trinucleotide repeats of PABPN1 gene this model may not be applicable for the generation of mutation in OPMD patients.Unequal cross over during DNA replication may be the underlying mechanism for (GCG) repeat. How to referenceIn order to correctly reference this scholarly work, feel free to copy and paste the following: Jnanankur Bag, Quishan Wang and Rumpa Biswas Bhattacharjee (2012).Nuclear Poly (A)-Binding Protein and Oculopharyngeal Muscular Dystrophy, Muscular Dystrophy, Dr. Madhuri Hegde (Ed.),

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.030
Threshold uncertainty score0.101

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0300.017

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.240
Teacher spread0.212 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2012
Admission routes1
Has abstractyes

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