Abstract 17020: Molecular Spect Imaging of Early Angioproliferative Group I Pulmonary Arterial Hypertension Using an Adrenomedullin Receptor Ligand
Bibliographic record
Abstract
Introduction: The main limitation in the development of drugs against pulmonary arterial hypertension (PAH) is the absence of a non-invasive and early marker of disease. Adrenomedullin (AM) is a vasodilator peptide predominantly cleared by pulmonary endothelial receptors. Hypothesis: Our lab has developed Pulmobind PB, an AM derivative radiolabeled with 99mTc for SPECT imaging of pulmonary circulation to detect non-invasively the anomalies of pulmonary circulation caused by PAH. Methods: An angioproliferative model of group I PAH was used. After a single subcutaneous injection of the vascular endothelial growth factor receptor blocker Sugen (20 mg/kg), rats were exposed to hypoxia for 3 weeks followed by normoxia for 4 weeks. PAH rats were compared to their littermate controls (normoxia for 7 weeks). After 7 weeks, Right ventricular (RV) structure, function and hypertrophy as well as lung 99mTc-PB uptake kinetics were assessed by echocardiography and SPECT analyses. Results: RV end-diastolic anterior ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".