Process analytical chemistry and chemometrics, Bruce Kowalski's legacy at The Dow Chemical Company
Bibliographic record
Abstract
With the passing of Bruce R. Kowalski in 2012, a true visionary for chemometrics and process analytical chemistry has been lost. Bruce made significant contributions in the area of chemometrics and process analytical chemistry when he was a professor of chemistry at the University of Washington. He developed new and innovative chemometrics technology and founded the Center for Process Analytical Chemistry. He inspired many students and visiting scholars and had a significant impact on the practice of industrial analytical chemistry. One of the companies that benefitted greatly from Bruce's work was The Dow Chemical Company. This publication attempts to summarize Bruce's legacy at Dow through a discussion of Dow's involvement in the beginnings of the Center for Process Analytical Chemistry and the ongoing research and applications of chemometrics by his former graduate students at The Dow Chemical Company. Copyright © 2013 John Wiley & Sons, Ltd.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.015 | 0.019 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.005 | 0.008 |
| Science and technology studies | 0.002 | 0.011 |
| Scholarly communication | 0.008 | 0.012 |
| Open science | 0.001 | 0.003 |
| Research integrity | 0.003 | 0.013 |
| Insufficient payload (model declined to judge) | 0.004 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".