Aliskiren, a novel renin inhibitor versus angiotensin-converting enzyme-inhibitor in advanced experimental diabetic nephropathy
Bibliographic record
Abstract
S7However, prorenin is increased in the ischaemic and diabetic eye, and by angiotensin II blockade.Recently, there has been interest in the role of the (pro)renin receptor [(P)RR] in ocular disease.The (P)RR has been localised to retinal blood vessels, and by our group to neurons and Müller cells.The (P)RR may have a pathological role in the injured retina, with (P)RR inhibition attenuating angiogenesis and leukostasis.Together these findings suggest that prorenin may be a target for therapeutic intervention in ocular diseases such as diabetic retinopathy.However, still to be determined is how prorenin and the (P)RR contribute to vascular, neuronal and dysfunction in retinal development and disease.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".