Bibliographic record
Abstract
Acute Phase Proteins -Regulation and Functions of Acute Phase Proteins 2 response genes, secondary response genes need new protein synthesis to establish full expression patterns. This complex regulation depends on an array of transcription factors that may be divided in four classes The first two classes of transcription factors are ubiquitous stress sensors that respond to external stress signals. Class I includes constitutively expressed transcription factors, such as NF-B and IRF3, activated by signaldependent post-translational modifications that affect their activation properties and nuclear localization. For example, cytoplasmic NF-B is rapidly translocated to the nucleus after LPS stimulation, and is involved in the induction of primary genes. Other transcription factors of this class include latent nuclear AP-1 transcription factors, such as c-Jun phosphorylated rapidly after LPS stimulation. Class II transcription factors, including C/EBP and AP-1 transcription factor family members, need new protein synthesis for LPSdependent stimulation. In addition to inducing secondary late gene expression, these transcription factors play a role in determining waves of time-dependent levels of gene expression. In macrophages, CCAAT/enhancer-binding protein (C/EBP ) expression is increased late after LPS induction (see below). The two last classes comprise tissue-restricted and cell-lineage transcription factors. The third category includes the macrophage-differentiation transcription factors PU.1 and C/EBP . Transcription factors of this class establish inducible cell-specific responses to stress and inflammation, by generating macrophage-specific chromatin domain modifications. The fourth category includes metabolic sensors of the nuclear receptor family, such as peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXR), activated respectively by fatty acids and cholesterol metabolites (Glass and Saijo, 2010). These ligand-dependent transcription factors are anti-inflammatory and link metabolism and tissue inflammation. Recent findings have uncovered a general view of the various regulatory mechanisms establishing differential gene-specific patterns of primary and secondary gene expression after LPS stimulation in macrophages. These studies have determined the role of transcription factors, chromatin modifications and structure in gene regulation from transcription start sites and proximal promoter elements, or from enhancers, with microarray data generating genome-wide expression patterns, global chromatin immunoprecipitation experiments (ChIPon-ChIP), real-time PCR analysis and massively parallel sequencing.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".