Raynaud's phenomenon secondary to rheumatoid arthritis may be predictive of more erosive disease
Why this work is in the frame
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Bibliographic record
Abstract
Using a standardized assessment, data were collected on a cross-sectional cohort of RA subjects ( n = 329; mean age 60.3 ± 0.7 years; 77% female; 76% erosions, 75% positive rheumatoid factor [RF]) who met the American College of Rheumatology criteria for RA and had been seen at a London, Ontario rheumatology clinical practice during the 6-month study period. Study participants were prevalent (follow-up) cases and new referrals. A subsequent chart review was performed to verify clinic data and also to collect data on all variables that were not available at the time of the clinic visit. RP was defined as pallor of the fingers along with rubor, cyanosis, or both. The mean disease duration was 12 ± 0.6 years. Seventy patients (22%) had RP. RP status was not related to gender, age, or disease duration. The mean age at onset of RP was 50.7 ± 2 years and the mean RP duration was 9.2 ± 1.5 years. Patients presented with RP a mean of 3.8 ± 1.4 years after the diagnosis of RA (95% confidence interval, 0.9–6.6 years; minimum, maximum = 31 years before RA diagnosis, 32 years after). RP status was not associated with the presence of nodules and erosions. Patients with sclerodactyly [all was distal to proximal interphalangeal joints] were more likely than those without to have RP (34% versus 17%, P < 0.001). Subjects with sclerodactyly (26%) were also more likely than those without to have erosions (86% versus 72%, P < 0.02). Patients who developed RP after their RA diagnosis were more likely to have erosions than those who developed RP before RA ( P < 0.005). As expected, positive RF was associated with longer disease duration ( P < 0.04). Higher RF values were associated with longer disease duration ( P < 0.005) and increased RP duration ( P < 0.01). RP was present in 22% of the RA patients seen in a rheumatology clinical practice in London, Ontario during the 6-month study period. RP appears to develop relatively soon (approximately 1–7 years) after RA diagnosis in the majority of cases. Idiopathic RP may be different from RP secondary to RA, the latter of which may be associated with more erosive RA. Sclerodactyly is associated with erosive arthritis and RP in RA. Higher RF values were indicative of increased RA and RP duration.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it