Hematological Problems in Pediatric Intensive Care
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Abstract
Desmopressin (1-deamino-8-D-arginine vasopressin, DDAVP) has been used in children with von Willebrand disease (VWD) and Hemophilia A for almost 35 years. This treatment has substantially lowered the number of children exposed to human plasma derived products, with a good safety profile, and at very low cost. The response to DDAVP has been shown to be associated with age, baseline factor level, and genetic mutations. A DDAVP challenge test is recommended. DDAVP has also been used to prevent and treat bleeding episodes in children with platelet function defects and other disorders associated with bleeding tendency.
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The record
- Venue
- Pediatric and adolescent medicine
- Topic
- Hemophilia Treatment and Research
- Field
- Medicine
- Canadian institutions
- Hospital for Sick ChildrenUniversity of TorontoUniversité de MontréalSickKids FoundationCentre Hospitalier Universitaire Sainte-Justine
- Funders
- —
- Keywords
- MedicineIntensive care medicineRandomized controlled trialClinical trialFactor VIIaRecombinant factor VIIaPediatricsSurgeryInternal medicine
- Has abstract in OpenAlex
- yes