Antitumor activity of sphingosine‐1‐phosphate (1013.20)
Bibliographic record
Abstract
Sphingosine‐1‐phosphate (S1P) is an endogenous metabolite derived from ceramide as part of the sphingomyelin cycle. It is a potent molecular messenger which exerts its function both intracellularly and extracellularly. Intracellularly, S1P acts as a second messenger regulating calcium mobilization, and cellular proliferation and survival. Extracellularly, S1P acts as a ligand of the G‐protein‐coupled S1P receptors (S1PRs) and mediates a variety of physiological and pathological processes. Levels of S1P and other sphingosine metabolites are maintained in a delicate balance through the action of two enzymes, sphingosine kinase (SK) and sphingosine‐1‐phosphate lyase (SPL). Our previous studies showed that exogenously administered S1P (concentration: 1 µM) exhibited synergistic effects with chemotherapy drugs in human breast cancer MCF7 and MDA‐MB‐361 cells [1, 2]. Herein, we report other cell lines and mouse xenograf study results on the antitumor activity of S1P.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".