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Record W1580074209 · doi:10.1186/cc1903

Use of anabolic steroid therapy in critically ill ICU patients

2003· article· en· W1580074209 on OpenAlexaff
Jill Pikul, MD Sharpe

Bibliographic record

VenueCritical Care · 2003
Typearticle
Languageen
FieldMedicine
TopicThermal Regulation in Medicine
Canadian institutionsWestern University
FundersNational Institutes of Health
KeywordsMedicineNitrogen balanceAnabolismMalnutritionLean body massEnteral administrationAnabolic steroidCritically illParenteral nutritionResting energy expenditureSarcopeniaProtein catabolismMedical nutrition therapyInternal medicineIntensive care medicineOxandroloneEnergy expenditureBody weightHormoneGrowth hormone

Abstract

fetched live from OpenAlex

Studies on head injury-induced pituitary dysfunction are limited in number and conflicting results have been reported.To further clarify this issue, 29 consecutive patients (24 males), with severe (n = 21) or moderate (n = 8) head trauma, having a mean age of 37 ± 17 years were investigated in the immediate post-trauma period.All patients required mechanical ventilatory support for 8-55 days and were enrolled in the study within a few days before ICU discharge.Basal hormonal assessment included measurement of cortisol, corticotropin, free thyroxine (fT4), thyrotropin (TSH), testosterone (T) in men, estradiol (E2) in women, prolactin (PRL), and growth hormone (GH).Cortisol and GH levels were measured also after stimulation with 100 µg human corticotropin releasing hormone (hCRH) and 100 µg growth hormone releasing hormone (GHRH), respectively.Cortisol hyporesponsiveness was considered when peak cortisol concentration was less than 20 µg/dl following hCRH.TSH deficiency was diagnosed when a subnormal P4 Determination of functional states during sepsis-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis using measurement of ACTH, cortisol, dehydroepiandrosterone-sulfate (DHEAS) and dehydroepiandrosterone (DHEA)

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.042
GPT teacher head0.338
Teacher spread0.296 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2003
Admission routes1
Has abstractyes

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