Novel insights in post‐infectious irritable bowel syndrome in experimental giardiasis (650.15)
Bibliographic record
Abstract
Giardia duodenalis infections can lead to post‐infectious irritable bowel syndrome (PI‐IBS), a disorder characterized by chronic visceral pain. Using a new model of post‐giardiasis IBS, this study aimed to reveal novel mechanisms responsible for PI‐IBS. Weaning rats were gavaged with live Giardia trophozoites (assemblages A or B). Visceral hypersensitivity was assessed 50 days post‐infection (DPI) by measuring blood pressure changes in response to jejunal/rectal balloon distension. Spinal cord expression of c‐fos was used as a marker of nociceptive signaling. Caco‐2 monolayers were used to assess non‐invasive E. Coli HB101 translocation, as well as the integrity of epithelial barrier structure and function at early time points. c‐fos activation was observed during the acute phase. While the infection was cleared by 21DPI, jejunal and rectal hypersensitivity was observed 50 DPI with either assemblage along with mast cell infiltration. In vitro challenge with Giardia also facilitated the paracellular translocation of E. coli, increased epithelial permeability, and disrupted the tight junctional (TJ) proteins occludin and claudin‐4. These data show that Giardia‐induced IBS is associated with TJ proteins disruption, translocation of a commensal E. coli and c‐fos activation during the acute phase of the infection, as well as mast cell infiltration and visceral hypersensitivity. Findings in this model will help identify the mechanisms of Giardia leading to post‐giardiasis‐IBS. Grant Funding Source : Supported by the French ministry of secondary education and research, NSERC‐CREATE
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".