CD34 is required for the infiltration of inflammatory cells into the colon in a mouse model of ulcerative colitis (93.2)
Bibliographic record
Abstract
Abstract The infiltration of eosinophils into gut tissue and release of granular mediators appears to play a critical role in the pathogenesis of inflammatory bowel diseases (IBD) such as ulcerative colitis. Using an allergic asthma model, we recently demonstrated that eosinophil migration into the lung requires surface expression of the sialomucin CD34 on mast cells and eosinophils. Based in part on these findings, we have investigated a similar role for CD34 in the migration of eosinophils and other inflammatory cells into the colon, and the effects of CD34 deletion on IBD development using a dextran sodium sulfate (DSS)-induced model of ulcerative colitis. We monitored weight loss, colon length, rectal bleeding and diarrhea and our findings demonstrate decreased disease severity in DSS-treated Cd34-/- mice. Post-mortem histology of DSS-treated mice also showed reduced inflammation of Cd34-/- colon compared to wild type controls. Interestingly, the percentage of peripheral blood eosinophils was reduced significantly more in wild type than Cd34-/- mice at the disease endpoint - corroborating a defect in the exit of eosinophils from circulation into the gut. These findings support the conclusion that CD34 plays a role in eosinophil migration into gut tissues and suggest that CD34 may serve as a viable target for pharmacological interventions across a range of inflammatory conditions.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".