Connexin 43 Hemichannels and Pharmacotherapy of Myocardial Ischemia Injury
Bibliographic record
Abstract
Connexin (Cx) is the basic unit in the composition of gap junction channels but also exist in non-junctional unapposed hemichannels (Hc). The gap junction channels are formed by apposition of two hexameric CxHc from adjacent cells and play an essential role in cardiac function by allowing conduction of electrical impulse and exchange of biologically important molecules between myocytes. While most CxHc are engaged in gap junction formation, some unapposed Hc are present in association with various organelles (mitochondria, ER, etc.) but also in sarcolemma where they connect the intracellular and extracellular spaces. Recent evidence indicates that unapposed Hc in the plasma membrane perform functions different from those achieved by gap junction channels, mainly by providing pathways between the cytosol and the extracellular space allowing movement of ions and other small metabolites (Bennett et al., 2003; Goodenough & Paul, 2003), release of ATP and NAD+ (Bruzzone et al., 2001; Cotrina et al., 1998), regulation of cell volume (Quist et al., 2000), and the activation of survival pathways (Plotkin et al., 2002). These Hc are therefore believed to play a prominent role in cellular ion homoeostasis and signalling.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".