Bibliographic record
Abstract
BACKGROUND: Bone marrow CD34(superscript +) stem cells have significant promoting effects on angiogenesis. Presently, authors only searched one study concerning bone marrow CD34(superscript +) stem cells for treating angina pectoris by direct injection into ventricle in small samples. OBJECTIVE: To evaluate the safety and efficacy of transplantation of autologous bone marrow CD34(superscript +) stem cells for angina. DESIGN, TIME AND SETTING: The retrospective case analysis. PARTICIPANTS: A total of 32 patients suffered from angina were selected from the Department of Cardiology, General Hospital of Beijing Military Area Command of Chinese PLA from July 2007 to July 2008.They were randomly assigned into treatment and control groups. None of them had the history of acute myocardial infarction within 1 month before transplantation. Angina grade was from Ⅱ-Ⅳ grades by Canada Cardiovascular Association. No significant differences in baseline data were detected between two groups (P ＞ 0.05). METHODS: Following optimal drug treatment and conventional PCI, patients in the treatment group received autologous bone marrow CD34(superscript +) stem cell transplantation through coronary artery.15 mL of CD34(superscript +) stem cell suspension, about (1.0-6.1)×10^6 cells, was infused into the proximal end of coronary artery disease lesion. Patients in the control group only received optimal drug treatment and catheter implantation. MAIN OUTCOME MEASURES: Curative effect indices and hemoperfusion in patients of both groups following transplantation. RESULTS: Following bone marrow stem cell transplantation, angina pectoris attaches, nitroglycerin dose, movement time and Canadian Cardiovascular Society class indices were better in the treatment group compared with the control group (P＜0.001-0.05). At 6 months following transplantation, the therapeutic efficacy was better compared with that at 3 months. At 6 months, myocardial perfusion defect area was significantly smaller in the treatment group compared with the control group (P＜0.01).Within 6 months follow-up, myocardial infarction, cardiac enzyme elevation, perforation, pericardial effusion, ventricular tachycardia or ventricular fibrillation induced by intracoronary injection were not detected. CONCLUSION: Intracoronary transplantation of autologous bone marrow CD34(superscript +) stem cells is safe and efficient for angina, and can effectively improve myocardial hemoperfusion in angina patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".