Functional Interactions Between The Fibrosa And The Ventricularis Of Aortic Valve Leaflets
Bibliographic record
Abstract
Glutaraldehyde fixed porcine aortic valves are commonly used for the construction of bioprostheses, yet little is known about the function of the two major structural components of the valve leaflet (the fibrosa and ventricularis), or how each is individually affected by the fixation process. We therefore examined the function of the fibrosa and the ventricularis by separating them from the aortic valve leaflet and testing them individually. These mechanical tests showed the normal fibrosa and ventricularis to have very different elastic moduli and extensibilities. Aortic leaflet extensibility in the radial direction occurs mainly from the unfolding of the corrugatedfibrosa, whose folds are maintained by its attachment to the ventricularis. In contrast, the leaflets of glutaraldehyde fixed valves showed similar extensibilities and elastic moduli for the two layers. Such alterations in the function and interactions of valve leaflet components following fixation may contribute to the poor durability of glutaraldehyde fixed xenografts.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".