Adenosine receptor blockade impairs the ability of rat pups to autoresuscitate from primary apnea during repeated exposure to hypoxia (LB790)
Bibliographic record
Abstract
Autoresuscitation (AR) failure from hypoxic‐induced apnea by gasping has been suggested to play a role in sudden infant death. Little is known, however, about the factors that influence gasping and its ability to effect autoresuscitation in the newborn. The present experiments were carried out on 18 5‐6 day‐old rat pups to investigate the role of adenosine acting via A 1 receptors in mediating AR from hypoxic‐induced apnea by gasping. DPCPX (20 mg/kg; a selective adenosine A 1 ‐receptor antagonist) attenuated the heart rate response to hypoxia and decreased the number of hypoxic episodes tolerated before AR failure (DPCPX 10±2 (n=9) versus vehicle 17±5 (n=9); p<0.001). Following vehicle, death was preceded most often by AV dissociation whereas following DPCPX death was preceded most often by an isoelectric electrocardiogram. Thus, our data provide evidence that adenosine acting via A 1 receptors plays an important role in promoting AR from hypoxic‐induced apnea by gasping. Grant Funding Source : CIHR
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".