The Role of a Cell‐Associated Hyaluronan‐Binding Protein in Fibroblast Behaviour
Bibliographic record
Abstract
In a model culture system hyaluronan has been shown to promote cell ruffling and random cell locomotion. At the same time it promotes both protein tyrosine phosphorylation and phospholipid breakdown. These results indicate that this glycosaminoglycan, in addition to its previously described role as a regulator of adhesion and cytoskeletal organization, may also influence cell behaviour via second messenger formation. A cell-associated hyaluronan-binding protein (cell-HABP) has been isolated from locomoting fibroblasts that may represent one binding site that transduces these effects of hyaluronan. This protein is concentrated in the lamellae and ruffles of migrating fibroblasts but is lost from the cell surface as cell locomotion slows. It is a large (molecular mass estimated at 1-2 x 10(6) daltons) complex of proteins that includes a hyaluronan-binding site and a protein kinase. The protein kinase is responsive to hyaluronan and is related, antigenically, to the pp60src protein kinase. The function of cell-HABP has not been characterized but its location, regulated distribution and enzyme characteristics suggest that it may be involved in hyaluronan-regulated cell locomotion.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".