Studies on Subcellular Fractions from Mesenteric Arteries of Spontaneously Hypertensive Rats: Alterations in Both Calcium Uptake and Enzyme Activities
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Bibliographic record
Abstract
Calcium uptake and enzymatic activities were studied on plasma membrane-enriched and other subcellular fractions from mesenteric arteries of normotensive Wistar (NWR) and spontaneously hypertensive rats (SHR). The specific activities of plasma membrane marker enzymes (5’-nucleotidase, phosphodiesterase I, leucine aminopeptidase, and ouabain-sensitive K+-activated phosphatase) were significantly greater in the plasma membrane-enriched fraction from arteries of hypertensive than in those from normotensive rats. Alkaline phosphatase and Mg++-ATPase exhibited increased activities in all subcellular fractions of arteries from SHR as compared to those from NWR. The maximum calcium uptake in the presence of 5 mM ATP and 17 µM free calcium by the plasma membrane fraction from SHR arteries was significantly greater than that from NWR arteries. In contrast, the maximum ATP-independent calcium uptake in the presence of 1 mM free calcium by the plasma membrane fraction from SHR arteries was significantly lower than that from NWR arteries. The ionophore-induced decrease in calcium uptake by these fractions was 1.5–2.5 times greater for SHR than for NWR arteries. The presence of changes in activities of enzymes believed to be involved in
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it