Avaliação morfológica e molecular pós-tratamento com os fatores hepatotróficos, da cirrose hepática induzida em ratas pela tioacetamida: análise a curto e longo prazo
Bibliographic record
Abstract
Hepatic cirrhosis is an irreversible process characterized by an imbalance between deposition and degradation of extracellular matrix components (ECM).This disease leads to hepatocellular dysfunction and increased resistance to blood flow resulting in liver failure and portal hypertension.The cirrhosis, in dogs, is often identified in the final stages whereas the early stage is asymptomatic.In humans, in the final stage of the cirrhosis, transplantation is the only treatment.Thus, the search for alternative treatments becomes essential.The administration of hepatotrophic factors (HF) has been studied as a treatment alternative.This study evaluated the effects of HFs in murine liver cirrhosis induced by thioacetamide (TAA) immediately after treatment, and 60 days after it ends.75 female Wistar rats were distributed into four groups: HF (n=15) and control group (n=30), and HF +60d (n=15) and control group (n=15).Hepatic cirrhosis was induced in all animals by TAA administration (200 mg/kg), ip, 3 times a week for 14 weeks.After induction, two groups received the HFs solution for 12 days.One group was euthanized immediately after treatment and another group was euthanized 60 days after treatment.The following analyzes were performed: serum biochemistry, histopathologic, collagen quantification, cell proliferation, and stellate cells activation.In addition, the gene expression of proteins involved in fibrogenesis such as type 1 collagen, TGFβ-1, TIMP-1, MMP-2, MMP-13, and PLAU was evaluated.The results found immediately after treatment showed that HFs improved liver function, and reduced collagen deposition and stellate cells activation.Alterations of the molecular mechanisms involved in fibrogenesis were observed by reducing the expression of collagen type 1 and increased expression of TIMP-1, MMP-13 and PLAU.Most of these effects remained after the treatment.The results indicate that the HFs assist in restoration of liver function and architecture, acting on the mechanisms of deposition and degradation of ECM.Furthermore, the treatment with HFs showed prolonged action, remaining during the post-treatment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".