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Record W1608608933

Familial and Environmental Influences on Longevity in a Pre-industrial Population

2005· article· en· W1608608933 on OpenAlexaffabout
Ryan Mazan, Alain Gagnon

Bibliographic record

VenueScholarship@Western (Western University) · 2005
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics, Aging, and Longevity in Model Organisms
Canadian institutionsWestern University
Fundersnot available
KeywordsLongevityPopulationGeographyBiologyEnvironmental healthMedicineGenetics
DOInot available

Abstract

fetched live from OpenAlex

Data from historical populations provide an adequate context for the examination of the familial and environmental components of longevity. We have investigated the relation between sibling survivorship and longevity through French-Canadian children of a completed fertility cohort born between 1625 and 1704. The Cox regression model was used to analyze the effects of sibling survivorship on the survival time of these early Canadian inhabitants. Other covariates such as regional variation, secular trends (i.e. period effects), parental and spousal survival were also taken into consideration. Our findings show that individuals with at least one sibling surviving beyond 85 years of age had a life-long sustained mortality advantage over the general population. The risks of death after age 50 was 55% and 60% lower for females and males, respectively, having a long-lived sibling. In comparison, the parental of origin effects were negligible. Only the mother-son association in age at death was found significant among the four possible parent-child pairs. Overall, the various models provided better fit to male than to female data. Biological as well as social explanations are explored in order to account for the various results.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.683
Threshold uncertainty score0.637

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.047
GPT teacher head0.278
Teacher spread0.231 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2005
Admission routes2
Has abstractyes

Explore more

Same venueScholarship@Western (Western University)→Same topicGenetics, Aging, and Longevity in Model Organisms→French-language works237,207→