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Membrane Sodium Potassium ATPase Inhibition Mediated ATP Synthesis Induced by Digoxin, Photoinduction and Electromagnetic Fields

2012· article· en· W1624467811 on OpenAlexvenueno aff
A Ravikumar Kurup, Parameswara Achutha Kurup

Bibliographic record

VenueAdvances in natural science/Advances in natural sciences · 2012
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAdenosine and Purinergic Signaling
Canadian institutionsnot available
Fundersnot available
KeywordsDigoxinPotassiumSodiumATPaseChemistryInternal medicineEndocrinologyBiochemistryMedicineEnzymeHeart failure

Abstract

fetched live from OpenAlex

Aims and Objectives: Endogenous digoxin, exposure to sunlight and electric fields can produce membrane sodium potassium ATPase inhibition. Membrane sodium potassium ATPase in the setting of digoxin induced inhibition can synthesize ATP. The membrane sodium potassium ATPase mediated ATP synthesis can serve as a source for cellular energetics. This was studied and reported in this paper. Methodology: The following groups were included in the study: -endomyocardial fibrosis, alzheimer’s disease, multiple sclerosis, non-hodgkin’s lymphoma, metabolic syndrome x with cerebrovascular thrombosis and coronary artery disease, schizophrenia, autism, seizure disorder, creutzfeldt jakob disease and acquired immunodeficiency syndrome. There were 10 patients in each group and each patient had an age and sex matched healthy control selected randomly from the general population. The blood samples were drawn in the fasting state before treatment was initiated. Membrane sodium potassium ATPase was inhibited by the addition of digoxin at concentration 1 mg/ml and exposure to sunlight and low intensity electromagnetic fields for 1 hour. The ATP synthesis by membrane sodium potassium ATPase in the inhibited state was studied. Results: The results of the study showed increased ATP synthesis by RBC membrane sodium potassium ATPase in the presence of added digoxin, exposure to sunlight and low intensity electromagnetic fields. The added digoxin, exposure to sunlight and low intensity electromagnetic fields produce sodium potassium ATPase inhibition. Membrane sodium potassium ATPase in its inhibited state can synthesize ATP. The results are expressed as percentage change in the parameters after 1 hour incubation as compared to the values at zero time. There was RBC membrane sodium potassium ATPase mediated ATP synthesis in the patients with schizophrenia, malignancy, metabolic syndrome x, autoimmune disease and neuronal degeneration in the presence of added digoxin, exposure to sunlight and low intensity electromagnetic fields. Conclusion: The membrane sodium potassium ATPase inhibition mediated ATP synthesis may serve as a major source of cellular energetics. The sunlight induced photic induction of membrane sodium potassium ATPase inhibition may be a primitive source of cellular energy before the evolution of mitochondrial oxidative phosphorylation. The electromagnetic induction of membrane sodium potassium ATPase inhibition mediated ATP synthesis may also be a similar primitive source of cellular energy. The photic and electromagnetic inhibition mediated membrane sodium potassium ATPase inhibition related ATP synthesis still serves as a major source of cellular energetics despite the presence of mitochondrial oxidative phosphorylation and anaerobic glycolysis. Key words: Membrane sodium potassium ATPase; Digoxin; Photic induction; Electromagnetic fields; ATP synthesis

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.261
Teacher spread0.256 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2012
Admission routes1
Has abstractyes

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