The Gasotransmitter Role of Hydrogen Sulfide
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
A novel concept of "gasotransmitter" arrived recently. Gasotransmitters are small molecules of endogenous gases with important physiological functions. Their production and metabolism are enzymatically regulated, and their effects are not dependent on specific membrane receptors. Following the identification of nitric oxide and carbon monoxide as gasotransmitters, hydrogen sulfide (H(2)S) may be qualified as the third gasotransmitter. Recent studies have shown that H(2)S is generated from vascular smooth muscle cells (SMCs), catalyzed by specific H(2)S-generating enzyme. At physiologically relevant concentrations, H(2)S relaxes vascular tissues, an effect mediated by the activation of ATP-sensitive K(+) (K(ATP)) channels in vascular SMCs. H(2)S directly alters the activity of K(ATP) channels without the involvement of second messengers. Furthermore, the endogenous production of H(2)S in the cardiovascular system is likely regulated by nitric oxide, whereas the vasorelaxant effect of nitric oxide is inhibited by H(2)S. It is anticipated that future studies will better reveal the molecular mechanisms underlying the effect of H(2)S on K(ATP) channel proteins, the interaction of H(2)S and other gasotransmitters in cardiovascular system, the endogenous stimulators and inhibitors of H(2)S metabolism, the role of H(2)S in the regulation of heart function, and the abnormal H(2)S production and action under various pathophysiological conditions.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it