MétaCan
Menu
Back to cohort
Record W1636398037 · doi:10.1002/047001153x.g303113

Protein interactions in cellular signaling

2005· other· en· W1636398037 on OpenAlexaff
Tony Pawson

Bibliographic record

VenueEncyclopedia of Genetics, Genomics, Proteomics and Bioinformatics · 2005
Typeother
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicUbiquitin and proteasome pathways
Canadian institutionsLunenfeld-Tanenbaum Research Institute
Fundersnot available
KeywordsSignal transductionMechanism (biology)Protein–protein interactionProteomicsNucleic acidComputational biologySystems biologyBiologyCell signalingSecond messenger systemCell biologyBiochemistryGene

Abstract

fetched live from OpenAlex

Abstract Protein–protein interactions provide a fundamental mechanism through which cellular regulatory systems are organized, and specificity is imposed during signal transduction. Furthermore, the association of proteins into larger complexes supports the formation of more extended biochemical pathways and interaction networks that link and integrate different aspects of cellular behavior. The molecular principles that underlie protein–protein interactions also explain the ability of proteins to recognize specific phospholipids, nucleic acids, and second messengers, and, therefore, define a general theme in proteomics and cell biology.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.739
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.224
Teacher spread0.215 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2005
Admission routes1
Has abstractyes

Explore more

Same venueEncyclopedia of Genetics, Genomics, Proteomics and BioinformaticsSame topicUbiquitin and proteasome pathwaysFrench-language works237,207