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Record W1637133793 · doi:10.4212/cjhp.v61i6.96

Étude pilote de validation de l’administration de petits volumes de médicaments en pédiatrie par voie intraveineuse directe avec soluté primaire sur pompe volumétrique

2008· article· fr· W1637133793 on OpenAlexaffvenue
Jean‐François Bussières, Sonia Prot‐Labarthe, Karine Touzin, Denis Lebel, M.-H. Blond

Bibliographic record

VenueThe Canadian Journal of Hospital Pharmacy · 2008
Typearticle
Languagefr
FieldMedicine
TopicPharmaceutical studies and practices
Canadian institutionsCentre Hospitalier Universitaire Sainte-Justine
Fundersnot available
KeywordsGynecologyMedicineChemistry

Abstract

fetched live from OpenAlex

RESUME Introduction : Plusieurs systemes permettent l’administration intermittente de medicaments par voie parenterale (minisac, miniperfuseur, burette, administration directe). L’objectif de cette etude est de verifier la faisabilite de l’administration des medicaments de volumes inferieurs a 1 mL par la tubulure primaire d’un solute a debit fixe. Methodologie : Nous avons realise une etude experimentale pilote in vitro sans administration au patient. Des volumes de 1 mL ou moins de NaCl 23,4 % ont ete injectes dans la tubulure d’un solute d’eau sterile ayant un debit de 5 ou 10 mL/h. La proportion de NaCl perfusee a ete calculee par prelevements des quantites residuelles aux sites d’injection ou mesuree apres recueil des quantites reelles s’ecoulant de la tubulure. Resultats : Au total, 266 manipulations ont ete realisees. A un debit de 5 mL/h et apres une injection au site proximal, la proportion de NaCl perfusee etait superieure a la proportion theorique et les durees de perfusion, trop courtes. En revanche, apres une injection au site distal, la dose perfusee au meme debit etait administree de facon lente et previsible, soit toujours plus de 40% de la dose administree en 30 min. Enfin, apres une injection au site distal et au debit de 10 mL/h, l’administration d’une dose maximale de 1 mL avait une duree previsible de 30 min, avec 50% de la dose administree apres un maximum de 20 min de perfusion. Conclusion : Cette etude pilote confirme la faisabilite de l’administration de medicaments de volume inferieur a 1 mL en plus de 5 min par la tubulure primaire d’un solute a debit fixe. D’autres etudes seront necessaires pour confirmer l’application de cette methode en pediatrie.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.019

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.004
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0010.000
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.311
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2008
Admission routes2
Has abstractyes

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