New information from cell aggregate compression tests and its implications for theories of cell sorting
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
In order to verify theories about the mechanics of cell sorting, tissue spreading and checkerboard pattern formation, it is necessary to measure certain cell properties such as surface tension and adhesiveness. The purpose of this work is to clarify the relationship between these two important properties and to use computer simulations and analytical calculations to extract additional information from parallel plate compression tests. This paper shows that compression tests can be used to determine not only the surface tension between the aggregate and the surrounding medium, but also the effective viscosity of the cell cytoplasm and the interfacial tension that acts between the cells that make up the aggregate. The findings reported here also support a novel, differential interfacial tension-based theory for cell sorting, tissue spreading and checkerboard pattern formation, and pose further challenges to current differential adhesion-based models.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it