Inter- and intramolecular cycloaddition reactions of 2H-chromenes
Why this work is in the frame
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Bibliographic record
Abstract
The research described in this thesis concerns a study of a series of inter- and intramolecular cycloaddition reactions of the carbon-carbon double bond of 2H-chromenes. Firstly, a series of mono-2H-chromenes were prepared and it was shown that numerous intermolecular cycloaddition reactions could be performed. These findings were then applied to a C3-symmetric tris-2H-chromene in order to prepare complex polycyclic compounds in a highly efficient manner. For example, a cycloaddition reaction product was prepared in two steps from readily-available starting materials that contained seven fused rings and six stereogenic centres. Moreover, the regiochemistry and stereoselectivities of these cycloaddition processes were determined. A series of intramolecular cycloaddition reactions were then attempted on mono- and tris-2H-chromenes. It was found that intramolecular [2+2] cycloadditions proceeded adequately, however, intramolecular [2+4] cycloadditions were unsuccessful. Thus, preliminary investigations were then undertaken towards the synthesis of functionalized 2H-chromenes that would contain a more reactive carbon-carbon double bond.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it