Inter- and intramolecular cycloaddition reactions of 2H-chromenes
Bibliographic record
Abstract
The research described in this thesis concerns a study of a series of inter- and intramolecular cycloaddition reactions of the carbon-carbon double bond of 2H-chromenes. Firstly, a series of mono-2H-chromenes were prepared and it was shown that numerous intermolecular cycloaddition reactions could be performed. These findings were then applied to a C3-symmetric tris-2H-chromene in order to prepare complex polycyclic compounds in a highly efficient manner. For example, a cycloaddition reaction product was prepared in two steps from readily-available starting materials that contained seven fused rings and six stereogenic centres. Moreover, the regiochemistry and stereoselectivities of these cycloaddition processes were determined. A series of intramolecular cycloaddition reactions were then attempted on mono- and tris-2H-chromenes. It was found that intramolecular [2+2] cycloadditions proceeded adequately, however, intramolecular [2+4] cycloadditions were unsuccessful. Thus, preliminary investigations were then undertaken towards the synthesis of functionalized 2H-chromenes that would contain a more reactive carbon-carbon double bond.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".