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Record W1681816121 · doi:10.1021/bk-2005-0909.ch022

Cranberry Phenolics: Effects on Oxidative Processes, Neuron Cell Death, and Tumor Cell Growth

2005· book-chapter· en· W1681816121 on OpenAlex
Catherine Neto, Marva Sweeney‐Nixon, Toni L. Lamoureaux, Frankie Solomon, Miwako Kondo, Shawna L. MacKinnon

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueACS symposium series · 2005
Typebook-chapter
Languageen
FieldMedicine
TopicAntioxidant Activity and Oxidative Stress
Canadian institutionsInstitute for Marine BiosciencesUniversity of Prince Edward Island
FundersCranberry Institute
KeywordsFlavonolsProanthocyanidinChemistryApoptosisNeuroprotectionProgrammed cell deathCell growthHydrogen peroxideOxidative stressBiochemistryPharmacologyAntioxidantBiologyFlavonoidPolyphenol

Abstract

fetched live from OpenAlex

The North American cranberry (Vaccinium macrocarpon) is rich in natural phenolic compounds which contribute to its biological activity and potential therapeutic effect. Flavonols and anthocyanins from cranberry are potent radical scavengers which effectively protect low-density lipoproteins from oxidation in vitro. Whole cranberry extract was recently observed to exert neuroprotective effects in vitro under conditions of stroke. The incidence of hydrogen-peroxide-induced necrosis in rat brain neurons treated with whole cranberry extract was 48% lower than control and simulated ischemia-induced necrosis declined by 42%. Similar protective effects were observed for cranberry in rat brain neuron apoptosis assays. The relative contributions of each class of antioxidants is under investigation. Selective inhibition of tumor cell proliferation in a variety of tumor cell lines has been observed for triterpene phenolic esters and proanthocyanidin extracts isolated from whole cranberry. The nature and occurrence of these antitumor principles in cranberries is under further studies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.384
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.218
Teacher spread0.209 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it