Interactions between the ACE and the endothelin pathway
Bibliographic record
Abstract
Endothelin-1 (ET-1) is released from endothelial cells (EC) following gene activation of preproET mRNA and the subsequent proteolytic processing into biologically active peptide [1]. ET-1 activates ETB receptors on EC, promoting the release of endothelium-derived relaxing factor (EDRF), and ETA and ETB receptors on vascular smooth muscle cells (VSMC), promoting events coupled to both vasoconstriction and growth [2]. Activation of ETA/ETB receptors by ET-1 results in activation of the effector enzyme, phospholipase C (PLC) through a Gq-coupled receptor with the subsequent production of the hydrolytic products 1,4,5 inositol-trisphosphate (IP3) and diacylglycerol (DAG) [2]. These mediators subsequently promote [Ca2+]i release from sarcoplasmic reticulum (SR) stores and activate protein kinase C (PKC) respectively.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".