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Endosymbiotic Actinidic Archaea and Viroidal Induced Warburg Phenotype Can be Reversed by a Modified Vegetarian High Fiber, High Medium Chain Triglyceride Ketogenic Diet

2012· article· en· W1728950133 on OpenAlexvenueno aff
A Ravikumar Kurup, Parameswara Achutha Kurup

Bibliographic record

VenueAdvances in natural science/Advances in natural sciences · 2012
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMicrobial Metabolic Engineering and Bioproduction
Canadian institutionsnot available
Fundersnot available
KeywordsKetogenic dietMedium-chain triglycerideTriglycerideMevalonate pathwayEndocrinologyEndomyocardial fibrosisInternal medicinePopulationBiologyWarburg effectMedicineCholesterolGlycolysisEpilepsyBiochemistryFibrosisMetabolism

Abstract

fetched live from OpenAlex

Aims and Objectives: Actinidic archaea has been related to the pathogenesis of schizophrenia, malignancy, metabolic syndrome x, autoimmune disease and neuronal degeneration. The actinidic archaeal and viroid induced Warburg phenotype contributes to the pathology of the disease states mentioned. The possibility of administration of high medium chain triglyceride, high fiber vegetarian ketogenic diet on actinide based primitive organism like archaea with a mevalonate pathway and cholesterol catabolism was considered in these disease states. The effect of a high medium chain triglyceride and a high fiber modified vegetarian ketogenic diet on the Warburg phenotype was also studied. Methodology: The following groups were included in the study:- endomyocardial fibrosis, alzheimer’s disease, multiple sclerosis, non-hodgkin’s lymphoma, metabolic syndrome x with cerebrovascular thrombosis and coronary artery disease, schizophrenia, autism, seizure disorder, creutzfeldt jakob disease and acquired immunodeficiency syndrome. There were 10 patients in each group and each patient had an age and sex matched healthy control selected randomly from the general population. The blood was drawn from the (1) in freshly diagnosed cases and (2) after a 15-days modified vegetarian ketogenic diet of medium chain triglycerides (150 g of coconut oil), fiber (45 g of banana stem fiber) and vegetable proteins (black gram protein 100 g/day) with 50 g of carbohydrate (black gram polysaccharide). Plasma from fasting heparinised blood was used and the experimental protocol was as follows (I) Plasma+phosphate buffered saline, (II) same as I+cholesterol substrate, (III) same as II+rutile 0.1 mg/ml, (IV) same as II+ciprofloxacine and doxycycline each in a concentration of 1 mg/ml. The following estimations were carried out:- Cytochrome F420, free RNA, free DNA, hexokinase activity and archaeal cholesterol oxidase activity as indicated by liberation of hydrogen peroxide. Results: Plasma of control subjects showed increased levels of the above mentioned parameters with after incubation for 1 hour and addition of cholesterol substrate resulted in still further significant increase in these parameters. The plasma of patients showed similar results but the extent of increase was more. The addition of antibiotics to the control plasma caused a decrease in all the parameters while addition of rutile increased their levels. The addition of antibiotics and rutile to the patient’s plasma produced the same changes but the extent of change was more in patient’s sera as compared to controls. The patients on modified vegetarian high fiber, high medium chain triglyceride ketogenic diet showed a decrease in all the parameters. Conclusion: An actinide dependent shadow biosphere` of archaea and viroids in the above mentioned disease states is described. High dietary fiber and medium chain triglyceride ketogenic diet suppressed actinidic archaeal and viroidal growth, cholesterol oxidase activity and hexokinase activity. Thus the high fiber and medium chain triglyceride vegetarian ketogenic diet can inhibit the Warburg phenotype as well as has a antiarchaeal/viroidal effect. Key words : Modified ketogenic diet; Medium chain triglyceride; Fiber; Archaea; Viroid; Warburg phenotype

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.058
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.002
Science and technology studies0.0000.002
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.252
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2012
Admission routes1
Has abstractyes

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