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Record W1738990098 · doi:10.1017/cbo9780511809132.016

Polygenic inheritance, quantitative genetics and heritability

2003· book-chapter· en· W1738990098 on OpenAlexaff
Dick Neal

Bibliographic record

VenueCambridge University Press eBooks · 2003
Typebook-chapter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEvolution and Genetic Dynamics
Canadian institutionsUniversity of Saskatchewan
Fundersnot available
KeywordsBiologyTraitHeritabilityQuantitative geneticsGeneticsInheritance (genetic algorithm)Quantitative trait locusPolygeneAlleleEvolutionary biologyOrganismGeneSelection (genetic algorithm)Genetic variation

Abstract

fetched live from OpenAlex

So far we have considered characters determined by a single gene with two alleles, occurring in sharply contrasting states, which can have a major affect on the fitness of the organism. In some cases we are justified in modelling selection in this manner, but in many cases, probably the majority, we are not. It is possible to expand the basic theory to consider characters determined by two gene loci, but this approach is no longer useful when we consider characters that are determined by many genes. In these cases we may observe a general relationship between parent and offspring, which suggests that there is an underlying genetic basis to the trait, but we usually do not know how many genes are involved or how they interact. In addition, we may also be aware that the environment influences the trait to some extent. Consequently, in order to study these traits we examine their variability, and attempt to dissect this variation into its genetic and environmental components. This type of analysis is called quantitative genetics. We can consider three types of quantitative traits (Hartl and Clark 1989): Meristic traits in which the phenotype is expressed in discrete, integral classes. Examples include litter size or number of seeds produced per individual, number of flower parts, and kernel colour in wheat. Continuous traits in which there is a continuum of possible phenotypes. Examples include height, weight, oil content, milk yield, human skin colour, and growth rate. In practice, similar phenotypes are often grouped together into classes for the purposes of analysis. […]

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.002
Scholarly communication0.0010.001
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.215
Teacher spread0.199 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2003
Admission routes1
Has abstractyes

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Same venueCambridge University Press eBooks→Same topicEvolution and Genetic Dynamics→French-language works237,207→