Disability in women suffering from interstitial cystitis/bladder pain syndrome
Bibliographic record
Abstract
What's known on the subject? and What does the study add? Interstitial cystitis/bladder pain syndrome ( IC / BPS ) is a disease that is associated with significant disability in the areas of self‐care, sexual functioning, occupation, family and home responsibilities, and social functions. Compared to age‐ and cohort‐matched controls, patients with IC / BPS reported poorer mental and physical quality of life ( QoL ), as well as greater pain, depression, anxiety, catastrophizing, sexual dysfunction and less social support. In particular, catastrophizing and depression are suggested to be important for understanding the factors promoting a poorer QoL in IC / BPS . The findings of the present study suggest that psychosocial factors are significant in mediating the relationship between impairments and patient disability, with negative affect (i.e. depression, anxiety) and pain catastrophizing acting as significant mediators. These findings argue that catastrophizing and negative affect may be the mechanisms by which pain and symptoms elevate reports of patient disability. Understanding how pain and pain‐associated symptoms may become disabling through cognitive mechanisms represents an importance advance for IC / BPS management. Clinical interventions in women suffering from IC / BPS should target catastrophizing and mood for reduction using cognitive behavioural strategies aiming to decrease pain‐related disability. Objectives To examine a biopsychosocial framework of patient disability in patients suffering from interstitial cystitis/bladder pain syndrome ( IC / BPS ). To evaluate the impact of psychosocial factors on the relationship between pain and disability within women with IC / BPS . Patients and Methods Women with IC / BPS completed questionnaires including demographics, symptoms and problems ( IC Symptom and Problem Indices), pain (McGill Pain Questionnaire), quality of life (Medical Outcomes Study – Short Form 12), disability (Pain Disability Index) and psychosocial variables (Center for Epidemiological Studies – Depression Scale; State Trait Anxiety Inventory; Pain Catastrophizing Scale; Multidimensional Scale of Perceived Social Support). Exploratory and confirmatory factor analyses were employed to determine the factor structure and composition of the measured variables. Structural equation modelling was used to examine model fit and the mediation effect of the psychosocial factors (negative affect, catastrophizing and social support) on impairments and functional disability. Results Questionnaires completed by 196 women with IC / BPS provided data for the present study. The measurement model showed good fit to the data. Negative affect ( P < 0.001) and catastrophizing ( P < 0.001) were significant in explaining the relationship between impairments and functional disability, whereas social support did not. Conclusions Disability in patients suffering from IC / BPS is partially explained by the impact of negative affect and catastrophizing. As a result of the refractory nature of IC / BPS , patient management within a biopsychosocial framework represents an essential area of investigation. Decreases in negative affect and catastrophizing will probably lead to improvements in pain‐related disability.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".