Magnolol affects the expression of polyamine biosynthesis and catabolism‐linked proteins in PC3 human prostate cancer cells in vitro (1011.1)
Bibliographic record
Abstract
This study examined the effect of magnolol on the expression of proteins involved in polyamine biosynthesis/catabolism in PC3 prostate cancer cells in vitro . Magnolol, 80 μM for 6 hours, decreased cellular viability by ~50%. Magnolol exposure decreased expression of ornithine decarboxylase (ODC), a key protein in polyamine biosynthesis, and antizyme‐inhibitor (AZI) with no apparent change to expression of antizyme (AZ), an ODC inhibitor. Expression of spermidine/spermine N1‐acetyltransferase, a key protein in polyamine catabolism, was also decreased. These magnolol‐mediated changes to ODC & AZI expression suggest that changes in polyamine biosynthesis would occur. An AZI/AZ ratio decrease in response to magnolol favors growth repression of PC3 cells. Cellular signaling proteins were also evaluated, with no apparent change occurring in ERK1, ERK2, p‐ERK1, p‐ERK2, p38, p‐JNK2, PI3Kp110 & AKT expression. Decreased expression of p‐p38, JNK1, JNK2, PI3Kp85, p‐PI3Kp85 & p‐AKT and increased expression of p‐JNK1 were observed. This study demonstrates that magnolol can alter the behavior of human prostate cancer cells in vitro by affecting activities associated with growth regulation. (Supported by the Jeanne and J.‐Louis Levesque Foundation.) Grant Funding Source : Supported by the Jeanne and J.‐Louis Levesque Foundation
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".