Androgen effects on immune gene expression during parental care in bluegill sunfish (<i>Lepomis macrochirus</i>)
Bibliographic record
Abstract
Reproductive efforts are energetically costly and often result in significant trade-offs with other metabolic processes. In many animals, androgens influence how this energy is allocated during the breeding period. In this study, androgen levels of parental bluegill sunfish (Lepomis macrochirus Rafinesque, 1819) were manipulated by implanting males with either 11-ketotestosterone (11-KT) or flutamide (an androgen receptor antagonist) shortly after spawning. Parental behaviours were assessed for 3 days after implantation. Differential brain gene expression between the two groups was examined using a 44 000 microarray gene chip. We found that 11-KT-implanted males exhibited lower levels of expression of genes related to immune function compared with flutamide-implanted males, suggesting that high androgen levels negatively affect the male immune system. These data thus indicate that a significant trade-off may exist between maintaining high levels of androgens and decreased immune function in parental male bluegill.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".