Abstract 403: Metabolic Characteristics of Spontaneously Hypertensive Rats Compared With Normotensive Controls
Bibliographic record
Abstract
Objectives: To differentiate the metabolic responses of spontaneously hypertensive rats (SHR) compared to normotensive Wistar Kyoto (WKY) rats. Methods: Blood pressure and pulse wave velocity (PWV) measurements were conducted on 25 week old SHR and WKY rats. At the time of termination, vital organs were harvested and weighed, and serum was collected for analysis of blood lipids, liver enzymes, and urea levels. Results: SHR exhibited higher readings for mean arterial pressure (MAP) (p< 0.0001), peak velocity (PWV) (p=0.017), heart/body weight (BW) ratio (p<0.0001), and left ventricular wall/BW ratio (p<0.0001) compared to WKY. WKY displayed higher weight gain and blood lipid levels (serum triglycerides, total cholesterol, LDL-C, and HDL-C) compared to SHR (p<0.0001). Blood lipid levels were positively correlated with weight gain, and negatively correlated with MAP and left ventricular wall/body weight ratio. Weight gain and MAP were negatively correlated (r=-0.60, p<0.0001). Serum AST levels were higher among SHR compared to WKY (p=0.026), and serum AST was positively correlated with left ventricular wall/BW ratio (r=0.35, p=0.030). There was no correlation between AST levels and liver/BW ratio or MAP. Serum urea levels were higher among SHR compared to WKY (p=0.0032), and positively correlated with MAP (r=0.42, p=0.011) and heart/BW ratio (r=0.43, p=0.0096). There were no differences in kidney/BW ratios, however, the peri-renal adipose/BW ratio was lower in SHR compared to WKY (p=0.001), and negatively correlated with MAP (r=-0.41, p=0.018). Conclusion: The positive relationship between serum AST and left ventricular wall/BW ratio, but not liver/BW ratio, suggests a possible response to changes in cardiac muscle, independent of blood pressure. Serum urea levels responded to MAP and heart/BW ratio. These metabolic responses of SHR compared to WKY invite further investigation of possible mechanisms underlying the link with cardiovascular dysfunction.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".