Solid Silicon Microneedles for Safe and Effective Drug Delivery to Human Eye
Bibliographic record
Abstract
Guidelines on the fabrication of solid, out-of-plane Silicon (S i ) microneedles for drug delivery to the posterior segment of human eye have been provided. The posterior and the anterior chambers of the human eye have been studied along with the major obstacles to drug delivery, and thereafter a minimally invasive route for systematic drug delivery to the back segment was selected. Microneedle parameters were chosen so that drugs can be delivered successfully through the selected route. The entire fabrication process was simulated and the resultant micro structures have been reported and analyzed. A mechanical strength analysis was subsequently carried out for solid out-of-plane S i microneedles by using column buckling and bending forces. The data obtained from the analysis indicated that the fabricated needles should be able to withstand the pressure exerted by a thin layer of fibrous human tissue. Index Terms: Microneedle; posterior eye segment; ocular delivery; RIE; etch isotropy; tissue resistance; scleral route; cornea; ocular barrier. J. Elec. Engg., Instn. Engrs., Bangladesh, 36(II), December 2009: 28-34
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".