Chemotherapy Induced Cardiotoxicity: Facts, Breakthroughs, and Challenges.
Bibliographic record
Abstract
Chemotherapy involves the use of one or more cytotoxic drugs to kill rapidly dividing malignant cells. One of the most promising fields of chemotherapy is the so-called targeted therapy, where a group of antibodies and small-molecule kinase inhibitors are designed to target key proteins involved in growth and proliferation pathways. Today, targeted therapeutics, such as Imatinib mesylate (Gleevec), have radically transformed the treatment of solid tumors and some blood malignancies. Unfortunately, the emerging chemotherapy associated cardiotoxicity posing unexpected challenges that may limit effective use of these novel drugs. Drug-induced cardiotoxicity is associated with cardiac cell death, cardiac dysfunction, and can lead to life threatening heart failure. The mechanisms underlying this cardiotoxicity remain poorly understood. In this review we discuss the cardiotoxicity of some of the major anticancer chemotherapy drugs, and summarize recent insights into the mechanisms implicated in cardiac cell death and survival.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".