Bibliographic record
Abstract
> Les canaux ioniques dpendants du voltage (VGIC) reprsentent une large famille de protines canalaires assurant le passage d'ions de part et d'autre de la membrane plasmique. Les VGIC ont la particularit d'tre dots d'un domaine senseur de voltage (VSD). Cette unit rgule l'activit des VGIC en fonction des variations de potentiel membranaire. Rcemment, des mutations dcrites dans le VSD ont conduit la dcouverte d'une nouvelle voie de permation directement localise au sein de ce domaine : le pore omga. Au vu du grand nombre de protines prsentant un VSD et de leur rle crucial dans diverses fonctions physiologiques, dchiffrer le potentiel pathognique du pore omga s'avre dsormais essentiel. < Le mouvement du segment S4 possdant de 3 7 charges positives (apportes par des arginines et des lysines) induit un changement de conformation du pore aboutissant son ouverture, et donc au passage des ions. Rcemment, plusieurs tudes ont montr que des modifications du VSD peuvent gnrer une autre voie pour le passage des ions appele pore omga. L'objectif de cette revue est de prsenter le concept de pore omga, ses proprits biophysiques ainsi que son potentiel pathologique.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".