Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Virus pathogens that establish latent infections have double-stranded DNA genomes that are replicated in the host nucleus and include herpesvirus, polyomavirus, papillomavirus, and adenovirus. All viruses that form latent infections have evolved one or many methods to avoid elimination by the host immune system. The chapter discusses some of the many mechanisms employed by human cytomegalovirus (CMV) to circumvent host cell immunity. The molecular aspects of herpes simplex genome organization and its regulation of gene expression are described in greater detail than the other herpesviruses. Viral DNA synthesis initiated on circular molecules relies on viral proteins, including DNA polymerase, its processivity factor, an origin-binding protein, the single-stranded DNA binding protein, and a helicase-primase complex of three proteins, as well as unidentified host factors. Genital disease is different from the oropharyngeal form, in that the primary infection causes the most severe disease, while the recurrent form is the mildest. Live attenuated varicella vaccine, the first human herpesvirus vaccine licensed for clinical use and offering protection against disease in 85 to 95% of exposures, is recommended for routine vaccination in childhood and for susceptible older children and adults. Results from studies based on guinea pig cells support a role for adenovirus infection in the pathogenesis of chronic obstructive pulmonary disease (COPD) in which expression of the viral E1A enhances the inflammatory response of lung epithelial cells to noxious stimuli, be they cigarette smoke products, bacterial products, or environmental pollutants.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it