Out with the Old and in with the New: Hepatic Fibrosis Assessment in Canada

A rapid, reliable test, also acceptable to patients for the assessment of liver fibrosis, has long been the 'holy grail' of hepatology.The now dusty liver textbooks of yesteryear described percutaneous liver biopsy (PLB) -an ancient procedure that must seem archaic to patients.Although PLB remains germane to the artful management and careful diagnosis of particular diseases, its role in certain entities, such as viral hepatitis, is now questionable at best since FibroTest (LabCorp, USA) and FibroScan (Echosens, France) have become available in Canada.Even among common conditions such as steatohepatitis, liver biopsy may not exceed the minimum threshold of 'changing the patient's management' to justify its execution and cost and, as such, there appears to be increasingly fewer reasons to perform it.In fact, an entire generation of hepatologists have graduated their fellowship programs of late with ineptness in PLB, and I maintain that they are none the lesser for it.Of the gold standards, PLB is a flawed one for (at least) three reasons: most liver biopsies are inadequate in size and, thus, carry an inherent risk of inaccuracy (1); studies show a concerning interobserver variation among the pathologists who read them (1); and even if the specimen is of adequate size, diseases of the liver are all too often patchy, creating an intrinsic uncertainty in staging (2).Moreover, as a medical test, patients are, at the very least, highly inconvenienced by it, and while the majority sail through without major complications, a sufficiently high proportion of patients experience significant pain, not infrequently requiring admission to hospital or extended time away from work.Although also imperfect in head-to-head comparison studies with liver biopsy for accuracy, FibroScan and FibroTest have high F-statistics, and address many of the particular pitfalls of PLB, namely that of morbidity risk (3).As such, FibroTest and FibroScan have a primary, indisputable role to play in fibrosis assessment.Current trends in Canadian physician practice patterns regarding PLB are well-reflected in a study published by Sebastiani et al (4) (pages 23-30) in the current issue of the Journal.They surveyed a collection of 104 physicians who are members of the Canadian Association of Gastroenterology and/or the Canadian HIV Trials Network caring for patients with liver disease; their results are both informative and largely unsurprising.The majority of survey participants, nearly twothirds of whom were gastroenterologists, required assessment of disease stage, and the greatest demand for fibrosis assessment was for patients with hepatitis C (76.9%).The authors found that noninvasive fibrosis assessment was ordered more frequently in patients with viral hepatitis than autoimmune hepatitis, likely reflecting that necroinflammatory activity of the latter is crucial information by which to guide immunosuppression.Similar to our recent study involving hepatologists who are members of the Canadian Association for the Study of the Liver (5), noninvasive modalities of fibrosis evaluation had an approximate 50% perceived reduction in the need for PLB.When one considers

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