Changes of Molecular, Cellular and Biological Activities According to microRNA-mRNA Interactions in Ovarian Cancer
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
microRNA is a noncoding RNA sequence, 20-22 nucleotides long, which functions in silencing gene expression. Changes in normal microRNA expression lead to cancer progression. The following study has been done to elucidate the changes in the expression of microRNAs in ovarian cancer compared to the normal expression because such comparison may lead to better understanding of ovarian carcinogenesis. In the tumor samples, out of 680 microRNA types, 230 show high expression, 295 show low expression and 155 are non-expressed. When we categorized microRNAs based on fold increase >50, we found 31 high and 89 low expressed microRNAs. The huge differences in aberrant expression show the extent of changes in microRNA activities. Using Cancerminer tool, we found the corresponding mRNA targets of these abberantly expressed microRNAs. We found that the most target genes which are captured by the data process are related to cellular proliferation and carcinogenesis.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it