Zygotic Associations and Multilocus Statistics in a Nonequilibrium Diploid Population
Bibliographic record
Abstract
The usual approach to characterizing and estimating multilocus associations in a diploid population assumes that the population is in Hardy-Weinberg equilibrium. The purpose of this study is to develop a set of summary statistics that can be used to characterize and estimate the multilocus associations in a nonequilibrium population. The concept of "zygotic associations" is first expanded to facilitate the development. The summary statistics are calculated using the distribution of a random variable, the number of heterozygous loci (K) found in diploid individuals in the population. In particular, the variance of K consists of single-locus and multilocus components with the latter being the sum of zygotic associations between pairs of loci. Simulation results show that the multilocus associations in the variance of K are detectable in a sample of moderate size (> or =30) when the sum of all pairwise zygotic associations is greater than zero and when gene frequency is intermediate. The method presented here is a generalization of the well-known development for the Hardy-Weinberg equilibrium population and thus may be of more general use in elucidating the multilocus organizations in nonequilibrium and equilibrium populations.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".