High fat diet alters homocysteine metabolism and hydrogen sulfide biosynthesis in mice (1116.3)
Bibliographic record
Abstract
High fat diets (HFD) are obesogenic and predispose to metabolic syndromes. Non‐alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, is characterized by hepatic steatosis with progression to steatohepatitis in advanced stages. Homocysteine (Hcy) levels are reportedly altered in patients with NAFLD, although the mechanisms responsible remain undefined. Since the liver is one of the principal sites regulating systemic Hcy levels, the objective of the present study was to investigate the effect of a HFD on hepatic Hcy metabolism. Mice were fed a control diet (10% kcal fat) or a HFD (60% kcal fat) for 5 weeks. Compared to control mice, mice fed a HFD gained more weight and developed fatty liver. Serum Hcy levels were significantly lower and corresponded with increased mRNA and protein expression of transsulfuration enzymes cystathionine‐β‐synthase and cystathionine‐γ‐lyase in the liver. Enhanced expression of transsulfuration enzymes also increased hydrogen sulfide biosynthesis in the liver of HFD fed mice. Preliminary results associate these responses to the regulation of hepatic oxidative stress. The significance of our findings as they related to obesity and NAFLD are under investigation
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".